ArticleNanoscale advances2026
Microfluidic engineering of pDNA nanogels in a coaxial flow reactor: process development, optimisation, scalability and
Article in Nanoscale advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Long-Term Biodistribution of FeInternational journal of molecular sciences · 2026Article
- Engineered Neutrophils in Translational Medicine: Gene Editing, Nanotechnology, and AI-Driven Clinical Breakthroughs.Advanced healthcare materials · 2026Review
- Introduction to high throughput synthesis, characterisation and optimisation of nanomaterials.Nanoscale advances · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymeric nanogels hold strong promise for gene delivery, but their production is often limited by poor scalability and inconsistent control over physicochemical properties. To address this challenge, we present a scalable microfluidic strategy for engineering carboxymethyl chitosan-grafted branched polyethyleneimine plasmid DNA nanogels (CMC-bPEI-pDNA NGs) using a coaxial flow reactor. This continuous flow platform enables precise control over nanogel formation, offering tunability in particle size, surface charge, and encapsulation efficiency. Through systematic process development and parametric optimisation - including investigations into hydrodynamics, mixing, reactor geometry, and effect of reagent concentrations - we designed a novel process achieving high-throughput, reproducible nanogel production suitable for
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.