ArticleFrontiers in endocrinology2025
Case Report: ACTH- and CRH-secreting pheochromocytoma as a very rare cause of ectopic Cushing syndrome.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Surgical management of ectopic Cushing's syndrome from a pulmonary carcinoid secreting CRH supported by intraoperative ACTH monitoring - a case report.Frontiers in endocrinology · 2026Article
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8 authors.
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Abstract
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) represents a rare clinical entity characterized by severe hypercortisolemia. Pheochromocytoma, a neuroendocrine neoplasm originating from chromaffin cells within the adrenal medulla, is itself an uncommon diagnosis. The phenomenon of ectopic hormone production by pheochromocytomas is exceedingly rare, occurring in less than 1% of cases. In most instances, hypercortisolemia associated with pheochromocytoma is attributed to aberrant ACTH secretion. This report presents an exceptional case of EAS caused by a pheochromocytoma exhibiting co-expression of both ACTH and corticotropin-releasing hormone (CRH).
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