Evidence map›Paper›PMID 41334414›Full record

ArticleFrontiers in public health2025

Digital interventions addressing the unmet needs of older adults with multimorbidity: a mixed-methods persona design approach.

Vincenzo De Luca, Michele Virgolesi, Alessandra Cuomo, Daniela Lemmo, Mariangela Perillo, Federica Canfora, Sara Aprano, Fabrizio Mezza, Claudia Vetrani, Maria Francesca Freda and 8 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Vincenzo De LucaDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Napoli, Italy.
Michele VirgolesiDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Napoli, Italy.
Alessandra CuomoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Napoli, Italy.
Daniela LemmoDipartimento di Studi Umanistici, Università degli Studi di Napoli Federico II, Napoli, Italy.
Mariangela PerilloDipartimento di Architettura, Università degli Studi di Napoli Federico II, Napoli, Italy.
Federica CanforaDipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università degli Studi di Napoli Federico II, Napoli, Italy.
Sara ApranoCentro Italiano per la Cura e il Benessere del Paziente con Obesità (C.I.B.O), Azienda Ospedaliera Universitaria Federico II, Napoli, Italy.
Fabrizio MezzaDipartimento di Studi Umanistici, Università degli Studi di Napoli Federico II, Napoli, Italy.
Claudia VetraniDipartimento di Benessere, Nutrizione e Sport, Università Telematica Pegaso, Napoli, Italy.
Maria Francesca FredaDipartimento di Studi Umanistici, Università degli Studi di Napoli Federico II, Napoli, Italy.
Daniela AdamoDipartimento di Neuroscienze e Scienze Riproduttive ed Odontostomatologiche, Università degli Studi di Napoli Federico II, Napoli, Italy.
Teresa ReaDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Napoli, Italy.
Lorenzo MercurioDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Napoli, Italy.
Erminia AttaianeseDipartimento di Architettura, Università degli Studi di Napoli Federico II, Napoli, Italy.
Enrica MendittoDipartimento di Farmacia, Università degli Studi di Napoli Federico II, Napoli, Italy.
Annamaria ColaoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Napoli, Italy.
Guido IaccarinoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Napoli, Italy.
Maddalena IllarioDipartimento di Sanità Pubblica, Università degli Studi di Napoli Federico II, Napoli, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Frailty and multimorbidity in older adults require integrated, multidomain care models. Digital health solutions offer potential for improving self-management, but a structured methodology to translate the complex unmet needs of this population into tailored digital interventions is still lacking. Objectives: To propose and illustrate a mixed-methods, persona-based approach for mapping unmet needs of older adults with multimorbidity to candidate digital interventions. Methods: This study employed an explanatory sequential mixed-methods design. First, quantitative data from the SUNFRAIL+ frailty screening tool were analyzed for a sub-cohort of community-dwelling older adults with polypharmacy ( Results: SUNFRAIL+ data revealed a high prevalence of perceived memory loss (44.4%), reduced physical activity (40.7%), loneliness (29.6%), and gaps in primary care access (25.9%). Thematic analysis highlighted unmet needs in medication management, motivation for lifestyle change, social isolation, and environmental barriers. The persona "Gennaro" embodied these challenges, facilitating the identification of targeted digital solutions, including Shared Care Plans, Telemonitoring, smart pillboxes for Medication Adherence, Adapted Physical Activity programs, Motivational Interviewing apps, and Ambient Assisted Living (AAL) systems. A foundational dataset and interoperability requirements for implementation were also defined. Conclusion: This descriptive, hypothesis-generating study integrates quantitative screening and multidisciplinary expert insights to propose a structured, persona-guided approach for profiling the multifaceted unmet needs of older adults with multimorbidity. We outline candidate digital options mapped to specific challenges as a preliminary framework to hypothesize person-centered, digitally supported care models. End-user co-design and validation are planned next to evaluate feasibility, usability, acceptability, and potential impact on self-management and adherence.

Indexed as

Health Services Needs and DemandMultimorbidityAgedAged, 80 and overFemaleFocus GroupsHumansIndependent LivingMaleNeeds AssessmentPolypharmacyQualitative ResearchTelemedicinedigital healthfrailtymixed-methodsmultimorbidityolder adultspersona-based designpolypharmacytelemedicine

Identifiers

PMID41334414
PMCPMC12665755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.