Evidence map›Paper›PMID 41334377›Full record

ArticleBioactive materials2026

Dual functional properties of a probiotic biofilm-decorated bone substitute to combat infection and promote osteoimmunomodulation.

Shiyuan Song, Wen Zhang, Hongmei Zhuang, Wei Wei, Shuyu Cheng, Dan Qiao, Yin Xiao, Yangheng Zhang, Fuhua Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiyuan SongNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Wen ZhangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Hongmei ZhuangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Wei WeiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Shuyu ChengNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Dan QiaoQinghai University Affiliated Hospital, Xining, 810000, China.
Yin XiaoSchool of Medicine and Dentistry & Institute for Biomedicine and Glycomics, Griffith University, QLD, 4222, Australia.
Yangheng ZhangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.
Fuhua YanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomology, Nanjing University, Nanjing, 210008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral and maxillofacial bone defects are prevalent and challenging to treat, often leading to significant complications such as infection and impaired healing. Enhancing the antibacterial and osteoimmunomodulatory properties of bone graft materials represents a promising approach to improve regenerative outcomes. In this study, we developed a hydroxyapatite scaffold coated with a biofilm of the probiotic

Indexed as

Akkermansia muciniphilaAnti-bacterial adhesionBoneIL-10OsteoimmunologyOsteoinductivityPI3K/AKT

Identifiers

PMID41334377
PMCPMC12666132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.