Evidence map›Paper›PMID 41334375›Full record

ReviewBioactive materials2026

Barrier-disrupting microneedle technology: Overcoming physical, physiological, and pathological skin defenses to enhance therapeutic efficacy.

Zeshi Jiang, Wentao Wu, Tianxiang Chen, Wanshan Hu, Xinyu Zhang, Chunxian Zhou, Anqi Lu, Yan Yan, Guilan Quan, Chuanbin Wu and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
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  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zeshi JiangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Wentao WuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Tianxiang ChenSchool of Mechatronic Engineering, Guangdong Polytechnic Normal University, Guangzhou, 510665, China.
Wanshan HuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Xinyu ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Chunxian ZhouState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Anqi LuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Yan YanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Guilan QuanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Chuanbin WuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Xin PanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, United States.
Chao LuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.
Tingting PengState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedles (MNs) have gained increasing attention as an advanced transdermal delivery platform owing to their enhanced delivery performance compared to traditional systems. The key to enhancing MNs efficacy lies in overcoming multiple skin barriers that hinder efficient skin insertion and drug permeation: (1) Physical barriers, such as the tough stratum corneum and skin elasticity, impede complete MN insertion; (2) Physiological barriers, including the extracellular matrix (ECM) and biofilms, limit drug diffusion into deeper skin layers for optimal absorption; (3) Pathological microenvironments lead to uncontrollable drug release and insufficient drug accumulation in target tissue. In this review, we outline strategies to address these barriers for improved therapeutic outcomes. First, we discuss optimization approaches for MN geometry, administration methods, and separation performance to enhance skin penetration efficiency. Next, we explore passive (

Indexed as

Drug delivery efficiencyMicroneedleSkin barriersSkin puncture rateTransdermal permeability

Identifiers

PMID41334375
PMCPMC12666373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.