ArticleJournal of current ophthalmology
A Novel Oxygen Chamber for Corneal Cross-Linking in a High-Oxygen Environment: A Pilot Study and Clinical Outcomes.
Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
Purpose: To evaluate the safety and efficacy of increased environmental oxygen using a novel oxygen chamber during corneal cross-linking (CXL) in patients with keratoconus (KCN). Methods: This prospective interventional pilot study included 20 eyes from 15 patients with documented progressive KCN. Patients underwent epithelium-off accelerated CXL (irradiance of 9 mW/cm² for 10 min) in two different environments. The study group received CXL using an oxygen chamber providing a high-oxygen environment (60%), while the control group underwent CXL under ambient oxygen conditions (21%). Outcome measures included visual and topographic outcomes, demarcation line depth, endothelial cell count, and dry eye evaluation. Follow-up visits were conducted up to 6 months post-CXL. Results: Seventeen eyes completed the follow-up (study: 10 and control: 7). At 1-month postoperation, the study group exhibited a significantly deeper demarcation line, particularly at the inferior 3 mm location (250.8 μm vs. 169.3 μm, Conclusion: The findings of this pilot study show that the novel oxygen chamber can safely and effectively enhance CXL outcomes by creating a hyperoxic environment.
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