Evidence map›Paper›PMID 41334200›Full record

ReviewFrontiers in plant science2025

LRR-RLK subfamily II of coreceptors: emerging, non-canonical and canonical roles in plant antiviral immunity and development.

Fellipe R Sampaio, Beatriz M Takagaki, Sâmera S Breves, Raquel G Rodrigues, Viviano G O Neves, Félkerson M Ferreira, Nathália G A Ribeiro, Eulálio G D Santos, Pedro A B Reis, Elizabeth P B Fontes

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Processing and release of endogenous immunogenic peptide signals.The Plant journal : for cell and molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fellipe R Sampaio *Department of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Beatriz M Takagaki *Department of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Sâmera S BrevesDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Raquel G RodriguesDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Viviano G O NevesDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Félkerson M FerreiraDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Nathália G A RibeiroDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Eulálio G D SantosDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Pedro A B ReisDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.
Elizabeth P B FontesDepartment of Biochemistry and Molecular Biology, BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, Viçosa, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coreceptors act together with receptors in the process of signal transduction. Within the LRR-RLK subfamily II, coreceptors play an essential role by serving as a connection between growth and immunity in plants. The 14 LRRII-RLK identified genes in Arabidopsis have been phylogenetically clustered in four closely related groups. Three of them have been functionally characterized: (i) NIKs, which are associated with responses to viral infections, (ii) SERKs, which are involved in both development and immunity, and (iii) CIKs, which are connected to homeostasis, growth, and meristem development, as well as to a lesser extent, immunity. Currently, LRRII-RLKs have been more intensively investigated as potential antiviral mechanisms due to their emerging roles in antiviral immunity and their potential of being targeted by viral manipulation. Despite their partial functional redundancy and interactions in immunity and developmental signaling mechanisms, targeting LRRII-RLKs through genetic manipulation may lead to the development of a broad-spectrum resistance to viral infections, while also preserving plant growth and yield.

Indexed as

antiviral immunityCIKcoreceptorsNSP-interacting kinasereceptor-like kinasesSERKsignaling hubs

Identifiers

PMID41334200
PMCPMC12666859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.