Evidence map›Paper›PMID 41334039›Full record

ArticleChemical science2026

Supramolecular host-guest modulated thermally activated delayed fluorescence for photodynamic therapy.

Xujun Qiu, Peiqi Hu, Angelica Sevilla-Pym, Jana R Caine, Zachary M Hudson

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xujun QiuDepartment of Chemistry, The University of British Columbia 2036 Main Mall Vancouver British Columbia V6T 1Z1 Canada zhudson@chem.ubc.ca +1-604-822-2847 +1-604-822-3266.ORCID https://orcid.org/0000-0002-6854-5934
Peiqi HuDepartment of Chemistry, The University of British Columbia 2036 Main Mall Vancouver British Columbia V6T 1Z1 Canada zhudson@chem.ubc.ca +1-604-822-2847 +1-604-822-3266.ORCID https://orcid.org/0009-0006-4591-1379
Angelica Sevilla-PymDepartment of Chemistry, The University of British Columbia 2036 Main Mall Vancouver British Columbia V6T 1Z1 Canada zhudson@chem.ubc.ca +1-604-822-2847 +1-604-822-3266.ORCID https://orcid.org/0009-0006-7208-5754
Jana R CaineDepartment of Chemistry, The University of British Columbia 2036 Main Mall Vancouver British Columbia V6T 1Z1 Canada zhudson@chem.ubc.ca +1-604-822-2847 +1-604-822-3266.
Zachary M HudsonDepartment of Chemistry, The University of British Columbia 2036 Main Mall Vancouver British Columbia V6T 1Z1 Canada zhudson@chem.ubc.ca +1-604-822-2847 +1-604-822-3266.ORCID https://orcid.org/0000-0002-8033-4136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supramolecular host-guest chemistry can tune the photophysical behavior of organic emitters by confining them within well-defined nanoscale environments. Here we report a straightforward strategy to modulate the thermally activated delayed fluorescence (TADF) properties of organic emitters in aqueous media through complexation with the macrocyclic host cucurbit[7]uril (CB[7]). Upon formation of the TADF-CB[7] complex, the photoluminescence quantum yield is enhanced due to the suppression of non-radiative decay pathways within the rigid host cavity. Furthermore, host-guest encapsulation was found to accelerate both forward and reverse intersystem crossing, resulting in improved access to the triplet state. In the presence of molecular oxygen, this facilitates an increased generation of cytotoxic singlet oxygen, thereby boosting the efficacy of photodynamic therapy (PDT). These findings provide a promising supramolecular approach to advancing the application of TADF materials in aqueous-phase PDT systems.

Identifiers

PMID41334039
PMCPMC12666652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.