ArticleAmerican journal of ophthalmology case reports2025
Use of freeze-dried umbilical cord amniotic membrane as a corneal patch graft.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The use of amniotic membranes for corneal perforation management has been extensively documented, demonstrating significant potential in ocular surface reconstruction. However, their application in emergency settings remains underexplored. This report presents a novel use of freeze-dried umbilical cord amniotic membrane as a corneal patch graft, highlighting its practical benefits in urgent clinical scenarios. Case report: A 64-year-old male presented to the emergency department with a painful, red eye, having a history of penetrating keratoplasty. Slit-lamp examination revealed a severe corneal abscess with a 3 mm-wide paracentral perforation. Emergency surgery was performed using a freeze-dried umbilical cord amniotic membrane (SclerFix, Amtrix®, TBF) with a "mushroom plug and patch" technique, combined with a fresh amniotic membrane overlay. Postoperative treatment included oral antibiotics, topical antifungal agents, and antibiotic eye drops. The fresh amniotic membrane dissolved within days, while the freeze-dried umbilical cord membrane facilitated rapid re-epithelialization, effectively sealing the perforation. At three months postoperatively, the cornea remained intact without recurrence or complications, and the patient reported complete pain resolution. Conclusions: This case demonstrates the successful use of freeze-dried umbilical cord amniotic membrane as a corneal patch graft, avoiding emergency keratoplasty and preserving ocular integrity. This technique represents a promising alternative in situations where corneal grafts are not readily available. Further studies are warranted to validate its efficacy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.