ArticleSchizophrenia bulletin open2025
Patient Perspectives on a Digital Therapeutic for Schizophrenia: A Qualitative Evaluation of an App for Negative Symptoms.
Article in Schizophrenia bulletin open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05486312 (A Multi-center, Exploratory, Single-Arm, 7-week Study to Evaluate the Feasibility and Acceptability of Treatment With CT-155 in People With Schizophrenia), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-center, Exploratory, Single-Arm, 7-week Study to Evaluate the Feasibility and Acceptability of Treatment With CT-155 in People With Schizophrenia
Who cites it
2 citing papers in PubMed.
- A Digital Therapeutic Intervention for Negative Symptoms of Schizophrenia: A Randomized Clinical Trial.JAMA network open · 2026Trial
- AI-enabled passive digital phenotyping of experiential negative symptoms in schizophrenia-spectrum disorders: a narrative review on the path from sensing to clinical endpoints.Frontiers in psychiatry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Negative symptoms of schizophrenia are highly predictive of poor functional outcomes, and current treatment approaches have been minimally efficacious for these symptoms. CT-155/BI 3972080 (CT-155) is being developed as a smartphone-based digital therapeutic (DTx) rooted in evidence-based psychosocial interventions. Patient feedback on the usability, facilitators, and barriers to app use are of critical importance for long-term effectiveness of CT-155. Study Methods: This qualitative analysis explored user experiences with a beta version of CT-155 (CT-155 beta) following participation in an exploratory clinical study. Semistructured interviews were conducted with 42 participants at the end of a multicenter, 7-week, single-arm, open-label, study of CT-155 beta (NCT05486312). Thematic analysis was used to identify key patterns in participant experiences, focusing on usability, perceived benefits, and challenges. Study Results: Participant feedback revealed insights regarding: (1) usability of the app, (2) benefits of use, and (3) considerations for implementation. Participants described the app as accessible and easy to navigate, even among those with limited digital experience. The reported benefits included improved coping, increased motivation, increased social interest and skills, new thought patterns, and engagement with structured daily routines. Implementation considerations included technical issues, a desire for more personalization, and the influence of psychiatric symptoms. Conclusions: This study provides early insights into patient experiences after using CT-155 beta. The findings support the acceptability of the app and offer user-informed direction for future development. These results informed updates to the study app, which has been evaluated in a phase III confirmatory study.
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Registered trials
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