ArticleCureus2025
Primary Small-Cell Neuroendocrine Carcinoma of the Vagina: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intramedullary spinal cord metastasis from vaginal high-grade neuroendocrine carcinoma: A case report.Surgical neurology international · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-cell neuroendocrine carcinoma (SCNC) of the vagina is an exceedingly rare and highly aggressive tumor of the female genital tract. The vast majority of SCNCs occur outside the female genital tract, with gynecological involvement being remarkably rare. Despite modern advances in tumor genomic profiling, SCNC continues to demonstrate an aggressive clinical course and remains associated with an unfavorable prognosis. A 63-year-old woman presented to the Gynecology clinic with postmenopausal bleeding following a total abdominal hysterectomy with right salpingo-oophorectomy for uterine fibroids and a benign right ovarian cyst several years before. On assessment, a vaginal wall mass was discovered, and subsequent biopsy with histopathological assessment demonstrated an SCNC. Positron-emission tomography computed tomography confirmed primary vaginal SCNC with no metastatic foci. The patient subsequently underwent localized excision and was recommended for systemic treatment after a multidisciplinary team discussion. Following the first reported case many years ago, only a small number of cases have been documented in the medical literature. Due to the paucity of publications on SCNC of the vagina, there is currently no consensus on standard treatment protocols for this tumor. Therefore, we aim to raise awareness and research on this unique presentation of SCNC of the vagina.
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Registered trials
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