Evidence map›Paper›PMID 41333433›Full record

ArticleResearch square2025

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.

Rebecca Roddan, Matthew A Schaich, William J Nathan, Iulia Kis, Andrea Pierangelini, Lucy R Henderson, Raman van Wee, Louise Martin, Afaf El-Sagheer, Philipp Kukura and 7 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rebecca RoddanDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.ORCID https://orcid.org/0000-0002-9406-9011
Matthew A SchaichDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William J NathanLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Iulia KisDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.ORCID https://orcid.org/0009-0000-1672-2532
Andrea PierangeliniTarget Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, U.K.ORCID https://orcid.org/0009-0009-9396-619X
Lucy R HendersonDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.ORCID https://orcid.org/0000-0002-0142-5444
Raman van WeePhysical and Theoretical Chemistry, Department of Chemistry, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.ORCID https://orcid.org/0000-0001-8941-3693
Louise MartinDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.
Afaf El-SagheerSchool of Chemistry, University of Southampton, SO17 1BJ, U.K.
Philipp KukuraPhysical and Theoretical Chemistry, Department of Chemistry, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.ORCID https://orcid.org/0000-0003-0136-7704
Tom BrownChemistry Research Laboratory, 12 Mansfield Road, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, U.K.ORCID https://orcid.org/0000-0002-6538-3036
Darragh O'BrienTarget Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, U.K.ORCID https://orcid.org/0000-0003-4924-7795
Joseph A NewmanCentre for Medicines Discovery, University of Oxford, NDMRB, Oxford, OX3 7DQ, U.K.
David M WilsonBiomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Christopher J SchofieldChemistry Research Laboratory, 12 Mansfield Road, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, U.K.ORCID https://orcid.org/0000-0002-0290-6565
Bennett Van HoutenDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-4009-2478
Peter J McHughDepartment of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, U.K.ORCID https://orcid.org/0000-0002-8679-4627

Funding

Watching cooperative interactions between base and nucleotide excision repair proteinsR35ES031638 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bennett Van Houten · 2020 to 2026
$6.2M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Lumicks C-Trap Optical Tweezers with Confocal Fluorescence MicroscopeS10OD032158 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN HOUTEN, BENNETT · 2023 to 2023
$552k
DNA repair pathway coordination during damage processingF32ES034982 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHAICH, MATTHEW ALLEN · 2023 to 2025
$131k
NIEHS NIH HHS F32 ES034982NIEHS NIH HHS R35 ES031638NIGMS NIH HHS R01 GM129325NIH HHS S10 OD032158Wellcome Trust
6 · The paper itself

Abstract

The Cockayne Syndrome B (CSB,

Identifiers

PMID41333433
PMCPMC12668182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.