Evidence map›Paper›PMID 41333423›Full record

ArticleResearch square2025

Single-Cell RNA Sequencing Uncovers Neutrophil Clusters Associated with Autoimmune Neuroinflammation.

Yong Wang, William Turbitt, Lianna Zhou, Zhaoqi Yan, Sweta Patel, Wei Yang, Zhang Li, Jessica Buckley, Robert Welner, William Meador and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yong WangUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
William TurbittUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Lianna ZhouUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Zhaoqi YanUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Sweta PatelUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Wei YangUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Zhang LiUniversity of Alabama at Birmingham.
Jessica BuckleyUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Robert WelnerDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
William MeadorDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294.
Chander RamanDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294.
Hongwei QinUniversity Blvd, University of Alabama at Birmingham, Birmingham, AL, USA 35294.
Etty Benveniste19th Street South, ALGEN, Suite 835, University of Alabama at Birmingham, Birmingham, AL, USA 35294.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Project 3: LRRK2 mediated macrophage responses in PDP50NS108675 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STANDAERT, DAVID G. · 2018 to 2022
$9.9M
Astrocytic OSMR/JAK/STAT signaling in ADR01AG075057 · NIA · AUGUSTA UNIVERSITY · PI Hongwei Qin, Qin Wang · 2023 to 2026
$2.5M
Role of bone marrow Tregs in maintaining stromal cell functionR01HL150078 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELNER, ROBERT S · 2020 to 2023
$1.5M
O-GIcNAc regulation of mitochondrial function in astrocytes inneuroinflammatory Alzheimer's disease mouse modelR21AG081687 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI QIN, HONGWEI, ZHANG, JIANHUA · 2024 to 2024
$407k
NCI NIH HHS P30 CA013148NHLBI NIH HHS R01 HL150078NIAID NIH HHS P30 AI027767NIA NIH HHS R01 AG075057NIA NIH HHS R21 AG081687NINDS NIH HHS P50 NS108675
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. The Janus Kinase (JAK)/Signal Transducers and Activators of Transcription (STAT)/Suppressors Of Cytokine Signaling (SOCS) pathway regulates immune cell activity, with SOCS proteins functioning as negative regulators. Using the Experimental Autoimmune Encephalomyelitis (EAE) model of MS, our prior work demonstrated that mice lacking

Indexed as

Brain-targeted Experimental Autoimmune Encephalomyelitis (btEAE)NeutrophilsSAA3 (Serum amyloid A 3)Serum Amyloid A3 (SAA3)Single-cell RNA Sequencing (scRNA-Seq)Suppressors Of Cytokine Signaling 3 (SOCS3)

Identifiers

PMID41333423
PMCPMC12668163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.