ArticleResearch square2025
Estimating the incidence and risk factors of postpartum hemorrhage from the national ENACT network.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Aggregated counts from electronic health records (EHRs) provide a rich source of real-world data that can be leveraged to investigate critical medical conditions such as postpartum hemorrhage (PPH). We used the Evolve to Next-Gen Accrual to Clinical Trials (ENACT) network, a large, federated network of EHRs, and conducted repeated annual cross-sectional analyses on PPH incidence, risk factors, and maternal comorbidities in a large cohort of 591,375 delivery hospitalizations during the period 2005 to 2022. During this time, there was a statistically significant increasing trend in the incidence of PPH, which is consistent with previous studies. Native Hawaiian or Other Pacific Islander women had the highest incidence of PPH (12.14%), followed by Asian (11.04%) and Black or African American (9.36%) women. In PPH deliveries, the top-ranked risk factor was placenta previa or accreta (19.58%), the top-ranked comorbidity was primary cesarean delivery (41.08%), and the commonest cause was uterine atony (76.5%).
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