Evidence map›Paper›PMID 41333131›Full record

ArticleJID innovations : skin science from molecules to population health2026

Nanostring Transcriptomic Analysis Highlights IL-6 Family and TGF-β Pathways in the Pathogenesis of Prurigo Nodularis.

Yagiz Matthew Akiska, Shrey Bhatt, Kavita Vats, Selina M Yossef, Davies Gage, Shahin Shahsavari, Louis J Born, Perya Bhagchandani, Deena Fayyad, Hannah Cornman and 5 more

Abstract read
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In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yagiz Matthew AkiskaDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shrey BhattDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kavita VatsDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Selina M YossefDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Davies GageDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shahin ShahsavariDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Louis J BornDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Perya BhagchandaniDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Deena FayyadDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hannah CornmanDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Thomas PritchardDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jessica E TeagueDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Rachael A ClarkDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Madan M KwatraDepartment of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.
Shawn G KwatraDepartment of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prurigo nodularis (PN) is a chronic, neuroimmune-driven skin disease characterized by intensely pruritic nodules and marked impairment in QOL. Although PN shares inflammatory features with atopic dermatitis and psoriasis, its underlying pathogenesis remains poorly defined. In this study, we performed NanoString-based transcriptomic profiling on lesional skin biopsies from patients with PN (n = 26), those with atopic dermatitis (n = 25), those with psoriasis (n = 15), and healthy controls (n = 12) using a custom neuroinflammation-focused panel. PN demonstrated a unique molecular signature involving neuroimmune activation (

Indexed as

Extracellular matrix remodelingFibrosisItchPrurigo nodularisTranscriptomics

Identifiers

PMID41333131
PMCPMC12666349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.