Evidence map›Paper›PMID 41333053›Full record

ArticleFrontiers in molecular biosciences2025

Lemon-derived nanovesicles facilitate trans-kingdom transfer of lncRNAs to human cells.

Vincenza Tinnirello, Roberta Gasparro, Giulia Duca, Laura Miozzi, Silvia Rotunno, Francesco Mercati, Alice Conigliaro, Riccardo Alessandro, Stefania Raimondo

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vincenza TinnirelloDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.
Roberta GasparroDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.
Giulia DucaDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.
Laura MiozziInstitute for Sustainable Plant Protection, National Research Council of Italy (IPSP-CNR), Torino, Italy.
Silvia RotunnoInstitute for Sustainable Plant Protection, National Research Council of Italy (IPSP-CNR), Torino, Italy.
Francesco MercatiNational Research Council, Institute of Biosciences and Bioresources (IBBR), Palermo, Italy.
Alice ConigliaroDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.
Riccardo AlessandroDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.
Stefania RaimondoDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived nanovesicles (PDNVs) are emerging as a novel class of biological messengers, capable of crossing biological barriers and transferring bioactive molecules to human cells. We have previously isolated and characterized nanovesicles from lemon juice (LNVs) that interact with human cells, modulating the mechanisms of oxidative stress and inflammation. However, the mechanisms through which LNVs exert their effect are still poorly understood. Extensive researches have been conducted on the microRNA content of PDNVs, however the profile and role of long noncoding RNAs (lncRNAs) within the vesicles remain unexplored still. In the present study, the lncRNA cargo of LNVs and its role was investigated; highly conserved lncRNAs among

Indexed as

cross-kingdom regulationlemon nanovesicles (LNVs)long noncoding RNAs (lncRNAs)miRNA spongingplant-derived nanovesicles (PDNVs)

Identifiers

PMID41333053
PMCPMC12666425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.