SynthesisFrontiers in pediatrics2025
Optimizing pediatric AKI diagnosis: a patient-tailored meta-analysis of urinary TIMP-2/IGFBP7 performance across clinical scenarios and assay platforms.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity.World journal of pediatrics : WJP · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate the diagnostic value of urinary cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), for the early diagnosis of acute kidney injury (AKI) in children using a meta-analysis. Methods: Nine databases were searched (inception-May 2025). Two reviewers independently screened studies, extracted data, and assessed quality (QUADAS-2). Bivariate models (STATA 18.0) generated pooled estimates. Results: 15studies (1,338participants; 337 AKI cases) were included. Overall accuracy: Sensitivity 0.84 (95% CI: 0.71-0.91), Specificity 0.85 (95% CI: 0.76-0.91), AUROC 0.91. Key subgroups: High-risk Neonates: AUROC 0.96, NLR 0.13 (95% CI: 0.02-0.78), Critically Ill/Sepsis: AUROC 0.88, NLR 0.15 (95% CI: 0.04-0.64), ELISA testing: Sensitivity 0.88 (95% CI: 0.70-0.96), NLR 0.15 (95% CI: 0.05-0.43); NephroCheck® Test: AUROC 0.79; Funnel plot asymmetry suggested publication bias. Conclusions: TIMP-2/IGFBP7 show high diagnostic accuracy across pediatric settings, supporting their clinical utility. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251089957, PROSPERO CRD420251089957.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.