ArticleFrontiers in pediatrics2025
Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Introduction: This study investigates the role and underlying mechanism of hydrogen (H₂) in hyperoxia-induced bronchopulmonary dysplasia (BPD), aiming to provide a theoretical foundation for developing effective BPD treatment strategies. Methods: A hyperoxia-induced BPD rat model and a rat type II alveolar epithelial cell (RLE-6TN) injury model were established. H₂ was administered to assess its effects on BPD rats, while hydrogen-rich medium was used to treat RLE-6TN cells to evaluate cell viability. Results: H₂ treatment ameliorated lung tissue pathology in BPD rats, reduced cellular apoptosis, enhanced the expression of surfactant proteins SP-A and SP-B, and modulated AHR and its downstream effector CPEB4, thereby alleviating endoplasmic reticulum (ER) stress. Discussion: H₂ alleviates ER stress and reduces apoptosis by regulating AHR and its downstream molecule CPEB4, thereby mitigating hyperoxia-induced BPD. The protective mechanism of H₂ may be closely associated with the modulation of the AHR-CPEB4 signaling pathway and the attenuation of ER stress.
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