Evidence map›Paper›PMID 41332885›Full record

ArticleFrontiers in ophthalmology2025

Presentation, management, and outcomes of orbital infections in patients with cancer.

Ava Niknahad, Alison B Gibbons, Aishah Ahmed, Heya Lee, Setu Mehta, Samir Al-Ali, Meron Haile, Anjana Srikumar, Rachel Stemme, Akanksha Suresh and 4 more

Abstract read
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In one paragraph

Article in Frontiers in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ava NiknahadWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Alison B GibbonsWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Aishah AhmedWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Heya LeeWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Setu MehtaWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Samir Al-AliWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Meron HaileWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Anjana SrikumarWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Rachel StemmeWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Akanksha SureshWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Justin C ZhongJohns Hopkins University, Baltimore, MD, United States.
Fasika WoretaWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Emily LiWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.
Fatemeh RajaiiWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to characterize the presentation, treatment, and outcomes of preseptal and orbital cellulitis in patients with and without cancer, to help guide management of these infections. Methods: A retrospective cohort study was conducted at a tertiary care center to identify adults who presented from 2007 to 2022 with orbital and preseptal cellulitis. Patients with cancer were defined as patients actively receiving chemotherapy or in remission but on immunosuppressants at the time of their orbital infection care. Their demographics, presentation, management, and follow-up characteristics were recorded. Management variables included data on antibiotics, antifungals, and systemic steroids administered. Results: Of the 183 patients presenting with orbital cellulitis, 15 (8.2%) had active cancer while of the 130 patients with preseptal cellulitis, 8 (6.2%) had cancer ( Conclusions: Patients with cancer presenting with orbital cellulitis have a higher rate of antifungal administration and are started on systemic steroids later compared to patients without cancer, although they have similar eye exam outcomes and readmission rates. Patients with cancer are not at an increased risk of preseptal cellulitis and are managed similarly to patients without cancer.

Indexed as

cancerimmunosuppressionorbital cellulitisorbital infectionpreseptal cellulitis

Identifiers

PMID41332885
PMCPMC12665583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.