ArticlemedRxiv : the preprint server for health sciences2025
Feasibility and Preliminary Effectiveness of a Discrete Choice-Based Pre-Exposure Prophylaxis Delivery Model for Female Sex Workers in Uganda.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The current PrEP delivery models in Uganda do not fully address the socio-economic, cultural, and logistical challenges faced by female sex workers (FSW), resulting in low adherence, mistrust in the healthcare system, and missed opportunities for effective PrEP care, as reflected in national data. This study evaluated the feasibility and effectiveness of a discrete-choice PrEP delivery model to improve PrEP uptake, adherence, and outcomes among FSWs in Kampala, Uganda. We conducted a discrete choice experiment in October-November 2023 and identified an optimal model combining facility-based, health worker-led, in-person support with short message service (SMS) reminders. From March to May 2024, we implemented a pilot study to assess feasibility and preliminary effectiveness. We recruited 49 FSWs using peer-led snowball sampling at the Most At-Risk Population Initiative (MARPI) clinic at Mulago Hospital. We evaluated effectiveness using a pre-post design, comparing adherence scores at one and two months. Feasibility was measured using six 4-point Likert-scale items (score range 6-24; higher scores = greater feasibility). All 50 participants completed the follow-up. The median age was 27 years (IQR 21-30); most were Christian (86%), had primary education (55%), were single (76%), had sex with males (79%), and were in casual relationships (88%). Median adherence improved from 0.90 (IQR 0.83-0.93) at baseline to 1.00 (IQR 0.97-1.00) at two months. All 50 participants returned for their refill at the 2-month visit. Feasibility was high, with a mean score of 21.26 (SD 1.03). Integrating in-person facility-based support with SMS reminders significantly improved oral PrEP adherence among high-risk FSW. Improved adherence, full retention, and strong feasibility demonstrate the promise of combining face-to-face health care with mobile technology. Future research should examine the long-term effectiveness and scalability of this discrete-choice-informed model to sustain PrEP adherence among FSW.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.