ArticlemedRxiv : the preprint server for health sciences2025
Comparing Traditional and Newer Definitions of Obesity in Relation to Incident Cardiovascular Disease and Obesity-Related Cancer Risk: A Prospective Cohort Study in ARIC.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity is a risk factor for both cardiovascular disease (CVD) and cancer. The traditional body mass index (BMI)-based obesity definition (BMI ≥30 kg/m Methods: We analyzed 14,834 Atherosclerosis Risk in Communities (ARIC) study participants followed for a median of 25 years. Participants were classified as obese using the traditional definition (BMI ≥30 kg/m Results: 54% and 27% were classified as obese, respectively, according to the new-only (median BMI 26 kg/m Conclusion: Both obesity definitions identified increased CVD risk, with significant trends across groups. Only traditionally-defined obesity consistently showed increased risk for total and obesity-related cancers. The newer, more sensitive, definition identified a large cohort with intermediate CVD risk, not previously captured by BMI alone, highlighting a distinct risk profile, suggesting potential for targeted interventions. These findings warrant careful consideration of potentially inflated risk in patients defined as obese by the new criteria. Funding: NHLBI, NCI, NPCR, AHA.
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