ArticlemedRxiv : the preprint server for health sciences2025
Increased dose of H1N1 pandemic influenza vaccine during pregnancy improves immunity in mothers and infants.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00992719 (A Phase II Study In Pregnant Women to Assess the Safety and Immunogenicity of an Unadjuvanted Novartis H1N1 Inactivated Influenza Vaccine Administered at Two Dose Levels), which is not on this map. Not yet cited in PubMed.
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A Phase II Study In Pregnant Women to Assess the Safety and Immunogenicity of an Unadjuvanted Novartis H1N1 Inactivated Influenza Vaccine Administered at Two Dose Levels
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Abstract
Maternal-infant immunity against influenza is improved through vaccination during pregnancy. We conducted an in-depth analysis of antibody (Ab) responses in sera from pregnant and non-pregnant women immunized with an unadjuvanted inactivated influenza A (H1N1) monovalent vaccine during the 2009 pandemic (NCT00992719). Pregnant women received either the standard 15μg- or increased 30μg-dose, while non-pregnant women received the 15μg-dose. Ab specific for influenza hemagglutinin (HA), HA stalk, and neuraminidase (NA), as well as canonical functions of hemagglutination inhibition (HAI), microneutralization, and neuraminidase inhibition were examined at baseline, 21 days post-vaccination, at delivery, and in cord blood. Ab subclasses, Fc receptor binding, and Fc-mediated immune functions, including cellular cytotoxicity, phagocytosis, and complement deposition, were also assessed. The vaccine was well-tolerated and highly immunogenic in recipients; most participants had a ≥4-fold increase in Ab titers post-vaccination for HAI (HAI> 70%) and HA-specific IgG (IgG> 50%). Pregnant women who received the 15μg dose had a lower vaccine response in terms of NA-specific IgG and Fc receptor binding compared to the other groups. Immunization of pregnant women with the 30μg-dose resulted in more robust humoral immunity, including a larger number of HA Ab features reaching 4-fold increases compared to the other groups and a more durable antiviral function, and increased NA-specific Ab features that were transferred to the infant as compared to pregnant women who received the standard 15μg-dose. Increasing the antigen content in seasonal vaccines could be a means to enhance immunity against influenza in mothers and infants and deserves further study.
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