Evidence map›Paper›PMID 41332761›Full record

ArticlebioRxiv : the preprint server for biology2025

Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis.

Romie Angelo G Azur, Daniel Feliciano, Isabel Espinosa-Medina, Raghabendra Adhikari, Joaquin Lilao-Garzón, Ella Jensen, Ching-Po Yang, Tzumin Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Romie Angelo G AzurDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0000-3998-325X
Daniel FelicianoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Isabel Espinosa-MedinaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Raghabendra AdhikariJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Joaquin Lilao-GarzónJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Ella JensenLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Ching-Po YangLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Tzumin LeeDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0569-0111

Funding

Mechanisms of Neuronal Temporal FateR01NS134890 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TZUMIN LEE · 2024 to 2026
$1.6M
NINDS NIH HHS R01 NS134890
6 · The paper itself

Abstract

Cortical neurogenesis proceeds through a precise temporal program in which radial glia sequentially generate distinct neuronal subtypes and later glia, yet how post-transcriptional regulators coordinate these transitions remain poorly understood. We previously identified that a decreasing temporal gradient of the RNA-binding protein Imp encodes neural stem cell age in

Identifiers

PMID41332761
PMCPMC12667946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.