ArticlebioRxiv : the preprint server for biology2025
Lymphotoxin-driven cancer cell eradication by tumoricidal CD8
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
38 authors.
Hongyan XieMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Aiping JiangMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Aonkon DeyMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Joseph W DeanIovance Biotherapeutics, Inc., San Carlos, CA, USA.
Jonathan J PereraBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Neal P SmithMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Alex C Y ChenMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Seth AndersonMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Angelina M CicerchiaMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yi SunMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
William A MichaudDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Maria FlorentinMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jacy FangMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Or-Yam RevachMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Tatyana SharovaDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Aleigha LawlessDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Katherine H XuMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yuhui SongMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Bidish PatelMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jonathan D StevensDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.
William J LaneDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.
Derin B KeskinHarvard Medical School, Boston, MA, USA.
Sonia CohenMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Donald P LawrenceHarvard Medical School, Boston, MA, USA.
Ryan J SullivanHarvard Medical School, Boston, MA, USA.
Keith T FlahertyHarvard Medical School, Boston, MA, USA.
Genevieve M BolandMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Linda T NiemanMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Moshe Sade-FeldmanMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nir HacohenMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Debattama R SenMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Catherine WuHarvard Medical School, Boston, MA, USA.
Brian GastmanIovance Biotherapeutics, Inc., San Carlos, CA, USA.
Rongsu QiIovance Biotherapeutics, Inc., San Carlos, CA, USA.
Hequn YinIovance Biotherapeutics, Inc., San Carlos, CA, USA.
Alexandra-Chloé VillaniMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Robert T MangusoMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Russell W JenkinsMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6110-2148
Funding
The Computational Tumor Immunology Core (CTIC)U54CA272688 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Vivek Mittal · 2022 to 2026
$7.4MSystematic identification of minor histocompatibility antigens to address GVHDR01HL157174 · NHLBI · DANA-FARBER CANCER INST · PI HO, VINCENT TRIEN-VINH, KESKIN, DERIN B · 2022 to 2025
$3.0MGenetically engineered mouse model to improve therapy of NUT carcinomaR01CA285308 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Christopher A French, Derin B Keskin · 2023 to 2026
$2.6MDeciphering the Achilles Heel of Cancer ImmunotherapyDP2CA247831 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VILLANI, ALEXANDRA-CHLOE · 2019 to 2019
$2.5MDissecting the tumor-intrinsic and -extrinsic roles of TBK1 in tumor immunityR37CA283560 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Russell William Jenkins · 2023 to 2026
$2.4MMerkel cell polyomavirus HLA class I epitopes for generating therapeutic T cell-based cancer immunotherapyR01CA279391 · NCI · DANA-FARBER CANCER INST · PI Derin B Keskin · 2024 to 2026
$2.2MMechanisms of lmmunosuppression in MYCN-driven NeuroblastomaR01NS140967 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Hui Feng, Derin B Keskin · 2025 to 2026
$1.3MNCI NIH HHS DP2 CA247831NCI NIH HHS R01 CA279391NCI NIH HHS R01 CA285308NCI NIH HHS R37 CA283560NCI NIH HHS U54 CA272688NHLBI NIH HHS R01 HL157174NINDS NIH HHS R01 NS140967
Abstract
Tumor-infiltrating lymphocyte (TIL) therapy is FDA-approved for patients with treatment-resistant advanced melanoma, but the TIL subpopulations critical for tumor eradication remains incompletely understood. Using patient-derived TIL-melanoma co-cultures, we identified and characterized a novel subset of CD8
Indexed as
cell deathinterferonlymphotoxinmelanomatumor-infiltrating lymphocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.