Evidence map›Paper›PMID 41332728›Full record

ArticlebioRxiv : the preprint server for biology2025

Regulation of murine follicle-stimulating hormone β subunit transcription by newly identified enhancers.

Yangfan Jin, Hailey Schultz, Luisina Ongaro, Gauthier Schang, Xiang Zhou, Carlos Agustin Isidro Alonso, Michel Zamojski, German Nudelman, Natalia Mendelev, Shinsuke Onuma and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yangfan JinDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.
Hailey SchultzDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec.
Luisina OngaroDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.
Gauthier SchangDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.
Xiang ZhouDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.
Carlos Agustin Isidro AlonsoDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.
Michel ZamojskiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
German NudelmanDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
Natalia MendelevDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
Shinsuke OnumaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Corrine K WeltDivision of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, UT.
Louise M BilezikjianClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-5791-1217
Frederique Ruf-ZamojskiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
Daniel J BernardDepartment of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.ORCID 0000-0001-5365-5586

Funding

MOLECULAR MECHANISM OF AGONISM AT THE GNRH RECEPTORR01DK046943 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI STUART C. SEALFON · 1993 to 2026
$11.0M
Regulation of Follistatin Expression by ActivinR01HD046941 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BILEZIKJIAN, LOUISE M · 2004 to 2014
$3.5M
Primary Ovarian Insufficiency: Etiology and Comorbid DiseaseR01HD099487 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CORRINE K WELT · 2019 to 2026
$2.7M
Integrated systems biology of the pituitaryR56DK046943 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SEALFON, STUART C. · 2006 to 2024
$555k
NICHD NIH HHS R01 HD046941NICHD NIH HHS R01 HD099487NIDDK NIH HHS R01 DK046943NIDDK NIH HHS R56 DK046943
6 · The paper itself

Abstract

Activin-class ligands of the transforming growth factor β family induce follicle-stimulating hormone (FSH) production by pituitary gonadotrope cells in mice via the actions of the transcription factors SMAD3, SMAD4, and FOXL2, which bind to

Identifiers

PMID41332728
PMCPMC12667839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.