Evidence map›Paper›PMID 41332726›Full record

ArticlebioRxiv : the preprint server for biology2025

Biosynthesis of peptidic thiooxazole metallophores installed by multinuclear nonheme iron enzymes.

Mayuresh G Gadgil, Shravan R Dommaraju, Xiaopeng Liu, Alexander J Battiste, Miriam H Bregman, Douglas A Mitchell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mayuresh G GadgilDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0003-2749-1682
Shravan R DommarajuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-0565-1748
Xiaopeng LiuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Alexander J BattisteDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-4072-7007
Miriam H BregmanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0009-0007-4213-6693
Douglas A MitchellDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0002-9564-0953

Funding

A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
Discovery and Engineering of RiPP Natural ProductsR35GM158411 · NIGMS · VANDERBILT UNIVERSITY · PI Douglas Alan Mitchell · 2025 to 2026
$1.2M
NIAID NIH HHS R01 AI144967NIGMS NIH HHS R35 GM158411
6 · The paper itself

Abstract

Significant effort has been directed toward characterization of nonheme iron enzymes owing to their breadth of unique reactivity. Through genome mining, we identified a conserved biosynthetic gene cluster within Pseudomonadota encoding one such family, the multinuclear nonheme iron-dependent oxidative enzymes (MNIO, formerly DUF692). Using a representative gene cluster from

Identifiers

PMID41332726
PMCPMC12668002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.