Evidence map›Paper›PMID 41332709›Full record

ArticlebioRxiv : the preprint server for biology2025

N6-methyladenosine RNA methylation is a novel epitranscriptomic regulator of excessive alcohol drinking and vulnerability to relapse.

Riccardo Maccioni, Irene Lorrai, Itzamar Torres, Roberta Puliga, Vez Repunte-Canonigo, Pietro Paolo Sanna

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Riccardo MaccioniDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.
Irene LorraiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.
Itzamar TorresDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.
Roberta PuligaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.
Vez Repunte-CanonigoDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.
Pietro Paolo SannaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA 92037.

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Gene Network Perturbations in Alcohol Dependence - A Systems BiologyApproachR01AA021667 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2013 to 2026
$6.1M
NIAAA NIH HHS R01 AA021667NIAAA NIH HHS T32 AA007456
6 · The paper itself

Abstract

While internal RNA modifications have been known for decades, the contribution of epitranscriptomics to alcohol use disorder (AUD) remains unexplored. Here we investigated, for the first time, the role of the most abundant mRNA modification, N6-methyladenosine (m

Identifiers

PMID41332709
PMCPMC12667994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.