Evidence map›Paper›PMID 41332703›Full record

ArticlebioRxiv : the preprint server for biology2025

Myeloperoxidase impairs mucociliary transport on human airway epithelium.

Allison Boboltz, Vaidehi Rathi, Sahana Kumar, Gregg A Duncan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Allison BoboltzFischell Department of Bioengineering, University of Maryland, College Park, MD 20742.
Vaidehi RathiFischell Department of Bioengineering, University of Maryland, College Park, MD 20742.
Sahana KumarFischell Department of Bioengineering, University of Maryland, College Park, MD 20742.
Gregg A DuncanFischell Department of Bioengineering, University of Maryland, College Park, MD 20742.

Funding

Understanding alterations to mucus composition and function in asthmaR01HL160540 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI Gregg Duncan · 2022 to 2026
$2.1M
New biophysical and immunoregulatory mechanisms in neutrophil extracellular trap mediated lung dysfunction in cystic fibrosisF31HL176146 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI BOBOLTZ, ALLISON MARGARET · 2024 to 2025
$77k
NHLBI NIH HHS F31 HL176146NHLBI NIH HHS R01 HL160540
6 · The paper itself

Abstract

Dampening neutrophil-driven inflammation in the airways remains a challenge in treating cystic fibrosis (CF) lung disease. Myeloperoxidase (MPO) is a neutrophilic enzyme that produces reactive oxygen species and is highly concentrated in CF sputum samples. Greater MPO concentrations have been previously correlated with increased mucus plugging in bronchiectasis, suggesting that the enzyme could impair mucociliary transport. MPO reacts competitively with either thiocyanate (SCN

Identifiers

PMID41332703
PMCPMC12667835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.