ArticlebioRxiv : the preprint server for biology2025
SF3B1 phosphorylation is an evolutionarily conserved step in spliceosome activation carried out by the divergent, OTS964-insensitive kinase CRK9 in trypanosomes.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
SF3B1 is a subunit of the heptameric SF3B complex which, as part of the U2 small nuclear ribonucleoprotein, facilitates branch point recognition in pre-mRNA splicing. In addition to this early-stage function, it was recently shown that activation of the spliceosome depends on the phosphorylation of threonine-proline (TP) motifs in SF3B1's N-terminal domain (NTD) by cyclin-dependent kinase 11 (CDK11). This breakthrough result was made possible by the discovery of the CDK11-specific inhibitor OTS964. Trypanosomes are protistan parasites whose proteomes are highly divergent in sequence from those of model organisms, and thus their CDKs were generically named CDC2-related kinases (CRKs). We previously characterized the trimeric CRK9 complex of
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