Evidence map›Paper›PMID 41332675›Full record

ArticlebioRxiv : the preprint server for biology2025

Phase precession of spindle-slow oscillation coupling across the human brain.

Alex C Bender, Madeline Taubkin, Mia Y Bothwell, Kyle Pellerin, Milena K Pavlova, Rani A Sarkis, Sydney S Cash, Alice D Lam

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex C BenderDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5680-0128
Madeline TaubkinDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Mia Y BothwellDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Kyle PellerinDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Milena K PavlovaDepartment of Neurology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
Rani A SarkisDepartment of Neurology, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
Sydney S CashDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Alice D LamDepartment of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Teresa Gomez-Isla · 2019 to 2026
$36.5M
Neuroscience Resident Research ProgramUE5NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SYDNEY S CASH, Ziv Williams · 2024 to 2026
$2.6M
The Contribution of Late Onset Unexplained Epilepsy to Cognitive Decline and its Interaction with Vascular and Alzheimer's Disease PathologiesK23NS119798 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SARKIS, RANI · 2021 to 2025
$1.1M
Exploring the role of epileptiform activity in Alzheimer's DiseaseK23NS101037 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LAM, ALICE D · 2018 to 2022
$1.0M
Neurophysiological Correlates of Cognition Over Multi-Day Timescales in EpilepsyK23NS140388 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Alex Colbath Bender · 2025 to 2026
$469k
NIA NIH HHS P30 AG062421NINDS NIH HHS K23 NS101037NINDS NIH HHS K23 NS119798NINDS NIH HHS K23 NS140388NINDS NIH HHS UE5 NS065743
6 · The paper itself

Abstract

Spindles and slow oscillations (SO) are fundamental elements of the NREM sleep microarchitecture, often co-occurring in a phase-dependent manner, and this cross-frequency coupling is critical for the temporal coordination of neural activity in sleep. However, spindles and SO occur at different times in different regions, and it is unclear how the coupling of these oscillations is organized across the brain. Here, we provide evidence in humans for a novel spatiotemporal organization of spindle-SO coupling, characterized by a

Identifiers

PMID41332675
PMCPMC12667803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.