Evidence map›Paper›PMID 41332669›Full record

ArticlebioRxiv : the preprint server for biology2025

INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes in

Emily J Leptich, Priyadharshini Vijayakumar, Edward W Pietryk, Meredith I Williams, Rachel N Arey

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily J LeptichDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America.
Priyadharshini VijayakumarCenter for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, United States of America.
Edward W PietrykCenter for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, United States of America.
Meredith I WilliamsCenter for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, United States of America.
Rachel N AreyCenter for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, United States of America.ORCID 0000-0001-9941-3945

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Uncovering brain-wide molecular determinants of individual memory performance across lifespanDP2NS132372 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI AREY, RACHEL NICOLE · 2022 to 2025
$2.4M
Exploring the functional role of tubulin methylation and its regulation by mes-4/NSD in C. elegansF31GM151846 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PIETRYK, EDWARD · 2023 to 2024
$97k
NIGMS NIH HHS F31 GM151846NIH HHS P40 OD010440NINDS NIH HHS DP2 NS132372
6 · The paper itself

Abstract

Insulin/IGF growth factor (IGF) signaling (IIS) is a pleiotropic signaling pathway that functions across tissues to coordinate phenotypic changes in response to nutrient status. Thus, the ubiquity of the IIS pathway hinders efforts to elucidate the mechanisms driving specific IIS-related phenotypes, Previous research in the nematode worm

Identifiers

PMID41332669
PMCPMC12667922

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.