ArticlebioRxiv : the preprint server for biology2025
Zα and Zβ domains of ADAR1 and ZBP1 bind to G-quadruplexes with low micromolar affinity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
1 While it is well established that the Zα domains of ADAR1 and ZBP1 proteins bind Z-form-prone nucleic acids (Z-NAs), it has also been shown that the Zα domain of ADAR1 binds DNA G-Quadruplexes (GQ). However, no binding partner of the structurally homologous Zβ domain of ADAR1 has been identified to date. Based on AlphaFold and molecular dynamics simulations, it has recently been suggested that the Zβ domain of ADAR1 targets its substrate by recognizing GQs. Here, we provide the first experimental evidence for Zβ domain binding to select G-quadruplex RNA and DNA
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