Evidence map›Paper›PMID 41332665›Full record

ArticlebioRxiv : the preprint server for biology2025

NK cell immunotherapy administered at the time of HIV recrudescence is associated with viral control.

Liliana K Thron, Pongthorn Pumtang-On, Jae Woong Chang, Maxwell E Cantor, Ian Gorrell-Brown, Kelsie L Becklin, Zoe E Quinn, Ahmad F Karim, Aaron K Rendahl, Mary S Pampusch and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liliana K ThronDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0009-3867-6448
Pongthorn Pumtang-OnDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9837-8209
Jae Woong ChangDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Maxwell E CantorDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.
Ian Gorrell-BrownDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0000-2961-5824
Kelsie L BecklinDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-2904-7374
Zoe E QuinnDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0006-6420-3634
Ahmad F KarimAgile Vaccines and Therapeutic, Infectious Diseases Directorate, Naval Medical Research Command, Silver Spring, MD, USA.
Aaron K RendahlDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.
Mary S PampuschDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-6973-9474
Sofia A CasaresAgile Vaccines and Therapeutic, Infectious Diseases Directorate, Naval Medical Research Command, Silver Spring, MD, USA.ORCID 0009-0009-5239-0868
Vaiva VezysCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2520-809X
Branden S MoriarityDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-3031-3767
Pamela J SkinnerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-3388-1687

Funding

Activated NK CAR Cells to Cure HIVR01AI161017 · NIAID · UNIVERSITY OF MINNESOTA · PI MORIARITY, BRANDEN S, SKINNER, PAMELA J · 2021 to 2025
$3.8M
NIAID NIH HHS R01 AI161017
6 · The paper itself

Abstract

One barrier to developing an HIV-1 cure is viral reservoirs persisting within B cell follicles of lymphatic tissues, partly due to failure of HIV-specific cytotoxic cells to express the follicular-homing receptor CXCR5. We evaluated HIV-specific CAR/CXCR5 NK cells armored with IL-15 and a PD-1 knockout for

Indexed as

base editorCAR therapyHIVhumanized DRAGA miceNK cells

Identifiers

PMID41332665
PMCPMC12667934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.