Evidence map›Paper›PMID 41332651›Full record

ArticlebioRxiv : the preprint server for biology2025

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memory.

Julia J Winter, Marisol Hooks, Keegan S Krick, Alexandra Goldhamer, Ronald W DiTullio, Kyle S Czarnecki, Claude-Ericka Ekobeni, Chloe Han, Kiara L Rodríguez-Acevedo, Brandon W Hughes and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Julia J WinterEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0001-8518-0167
Marisol HooksEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Keegan S KrickEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Alexandra GoldhamerEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ronald W DiTullioInstitut de la Vision, Sorbonne University, 75012 Paris, France.
Kyle S CzarneckiEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Claude-Ericka EkobeniEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Chloe HanEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kiara L Rodríguez-AcevedoEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Brandon W HughesNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Molly EstillNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Collin D TeagueNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Aarthi W RamakrishnanNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Li ShenNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Eric J NestlerNash Family Department of Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Elizabeth A HellerEpigenetics Institute at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0002-2984-8705

Funding

Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ERIC J. NESTLER · 2019 to 2026
$16.5M
Molecular Studies of Cocaine Action in BrainR01DA007359 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1991 to 2025
$5.6M
Epigenetic mechanisms of sustained transcription across cocaine abstinenceR01DA052465 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2021 to 2026
$4.0M
Training Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6M
Chromatin-mediated alternative splicing in reward pathophysiologyDP1DA044250 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI HELLER, ELIZABETH A · 2017 to 2021
$2.6M
Advancing Nr4a1 as a novel target in cocaine use disorder.R41DA061874 · NIDA · RAFIAS LLC · PI HELLER, ELIZABETH A · 2025 to 2025
$405k
Pharmacological activators of Nr4a1 for the treatment of cocaine use disordersU18DA052513 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI HELLER, ELIZABETH A · 2020 to 2020
$233k
NIDA NIH HHS DP1 DA044250NIDA NIH HHS P01 DA047233NIDA NIH HHS R01 DA007359NIDA NIH HHS R01 DA052465NIDA NIH HHS R41 DA061874NIDA NIH HHS T32 DA053558NIDA NIH HHS U18 DA052513
6 · The paper itself

Abstract

In classic disease models, removing a pathological insult restores homeostasis. Yet, addiction persists far beyond the period of active drug use. Cocaine abstinence induces changes in gene expression and neuronal signaling in reward-related brain regions that limit recovery during abstinence. We found that 2 weeks of abstinence increased

Identifiers

PMID41332651
PMCPMC12667977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.