Evidence map›Paper›PMID 41332638›Full record

ArticlebioRxiv : the preprint server for biology2025

Recurrent Breast Cancer Cells Depend on

Kelley R McCutcheon, Josh Wu, Yasemin Ceyhan Ozdemir, Brock J McKinney, Sharan Srinivasan, Ayaha Itokawa, Oliver J Newsom, Anna Vigil, Douglas B Fox, Lucas B Sullivan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kelley R McCutcheonTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.
Josh WuTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.
Yasemin Ceyhan OzdemirTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.
Brock J McKinneyTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.
Sharan SrinivasanTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.
Ayaha ItokawaHuman Biology Division, Fred Hutchinson Cancer Center.
Oliver J NewsomHuman Biology Division, Fred Hutchinson Cancer Center.
Anna VigilHuman Biology Division, Fred Hutchinson Cancer Center.
Douglas B FoxDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine.
Lucas B SullivanHuman Biology Division, Fred Hutchinson Cancer Center.ORCID 0000-0002-6745-8222
James V AlvarezTranslational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Center.ORCID 0000-0003-2910-7621

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast CancerR01CA285322 · NCI · FRED HUTCHINSON CANCER CENTER · PI James V Alvarez · 2024 to 2026
$3.0M
NRF2 suppression of inflammatory signaling and its role in tumor progressionR01CA292658 · NCI · FRED HUTCHINSON CANCER CENTER · PI James V Alvarez · 2024 to 2026
$3.0M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA285322NCI NIH HHS R01 CA292658
6 · The paper itself

Abstract

Breast cancer recurrence remains a major clinical challenge, often associated with therapy resistance and altered metabolic states. To define metabolic vulnerabilities of recurrent disease, we performed a CRISPR knockout screen targeting 421 metabolic genes in paired primary and recurrent HER2-driven breast cancer cell lines. While both primary and recurrent tumors shared dependencies on core metabolic pathways, recurrent tumors exhibited selective essentiality for the

Indexed as

DHODH (dihydroorotate dehydrogenase)FerroptosisMetabolic vulnerabilityNucleotide salvagePyrimidine metabolismRecurrent breast cancer

Identifiers

PMID41332638
PMCPMC12667778

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.