Evidence map›Paper›PMID 41332623›Full record

ArticlebioRxiv : the preprint server for biology2025

Metabolic cross-talk promotes persistence of

Zongsen Zou, Jerome S Pinkner, Chloe L P Obernuefemann, Kent R Kleinschmidt, Denise A Sanick, Suzanne M Hickerson, Karen W Dodson, Jeffrey P Henderson, Scott J Hultgren, Michael G Caparon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Zongsen ZouDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Jerome S PinknerDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Chloe L P ObernuefemannDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Kent R KleinschmidtDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Denise A SanickDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Suzanne M HickersonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Karen W DodsonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Jeffrey P HendersonDepartment of Internal Medicine, Division of Infectious Diseases, Center for Women's Infectious Diseases Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0003-1755-3202
Scott J HultgrenDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Michael G CaparonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Funding

MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
EXPRESSION AND IRON-INDEPENDENT FUNCTIONS OF SIDEROPHORES IN URINARY TRACT INFECTR01DK099534 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2014 to 2018
$1.8M
Metabolomic Mechanisms of Nutritional Immunity in the Urinary TractR01DK111930 · NIDDK · WASHINGTON UNIVERSITY · PI HENDERSON, JEFFREY P · 2018 to 2021
$1.4M
NCEZID CDC HHS U54 CK000162NIDDK NIH HHS R01 DK051406NIDDK NIH HHS R01 DK099534NIDDK NIH HHS R01 DK111930
6 · The paper itself

Abstract

Catheter-associated urinary tract infections (CAUTI) account for 70%~80% of urinary tract infections (UTI) and can lead to adverse outcomes. Most CAUTIs are polymicrobial with resilient communities maintaining a consistent composition of species over time, despite antibiotic treatment and catheter replacement. However, the mechanisms promoting persistence are poorly understood. Here we examine how a chemical interaction between Gram-positive

Identifiers

PMID41332623
PMCPMC12667794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.