Evidence map›Paper›PMID 41332616›Full record

ArticlebioRxiv : the preprint server for biology2025

RNA switch model for localization and translation of the myelin basic protein mRNA.

Ved V Topkar, Vivian Wu, Lana T Ho, Nicholas Ambiel, Alex Valenzuela, Kailee Yoshimura, J Bradley Zuchero, Meng-Meng Fu, Rhiju Das

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ved V TopkarBiophysics Program, Stanford University, Stanford, CA, USA.
Vivian WuDepartment of Biochemistry, Stanford University, Stanford, CA, USA.
Lana T HoDepartment of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA, USA.ORCID 0000-0002-6846-2127
Nicholas AmbielDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Alex ValenzuelaDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Kailee YoshimuraDepartment of Biochemistry, Stanford University, Stanford, CA, USA.
J Bradley ZucheroDepartment of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA, USA.
Meng-Meng FuDepartment of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA, USA.
Rhiju DasDepartment of Biochemistry, Stanford University, Stanford, CA, USA.

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
Next-generation computational/chemical methods for complex RNA structuresR35GM122579 · NIGMS · STANFORD UNIVERSITY · PI Rhiju Das · 2017 to 2026
$7.2M
Oligodendrocyte cytoskeletal dynamics and transportZIANS009432 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FU, MENG MENG · 2021 to 2023
$3.9M
How Does 3' UTR Secondary Structure Program mRNA Transport in Myelination?R21NS123533 · NINDS · STANFORD UNIVERSITY · PI ZUCHERO, JOHN B · 2021 to 2021
$433k
Intramural NIH HHS ZIA NS009432NCI NIH HHS P30 CA124435NIGMS NIH HHS R35 GM122579NINDS NIH HHS R21 NS123533
6 · The paper itself

Abstract

Oligodendrocytes myelinate the central nervous system by extending cellular projections that ensheath axons and elongate to form lipid-rich myelin. Classic studies visualizing RNA dynamics showed that myelin basic protein (MBP), one of the most abundant myelin proteins, is locally synthesized at the myelin sheath through the transport and local translation of

Identifiers

PMID41332616
PMCPMC12667860

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.