Evidence map›Paper›PMID 41332612›Full record

ArticlebioRxiv : the preprint server for biology2025

Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of

Thu H Truong, Noelle E Gillis, Amy R Dwyer, Rosemary J Huggins, Kyla M Hagen, Sai Harshita Posani, Nuri A Temiz, Carlos Perez Kerkvliet, Ellie M Piepgras, Julie H Ostrander and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Thu H TruongDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis MN, USA.ORCID 0000-0003-2394-551X
Noelle E GillisMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.ORCID 0000-0002-0005-4194
Amy R DwyerMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.
Rosemary J HugginsBen May Department for Cancer Research, University of Chicago, Chicago IL, USA.
Kyla M HagenDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis MN, USA.
Sai Harshita PosaniMolecular Pharmacology and Therapeutics Graduate Program, University of Minnesota, Minneapolis MN, USA.
Nuri A TemizMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.
Carlos Perez KerkvlietMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.
Ellie M PiepgrasDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis MN, USA.
Julie H OstranderMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.
Geoffrey L GreeneBen May Department for Cancer Research, University of Chicago, Chicago IL, USA.
Carol A LangeMasonic Cancer Center, University of Minnesota, Minneapolis MN, USA.ORCID 0000-0003-2751-3976

Funding

Progesterone Receptor (PR) Signaling Cross Talk Drives ER+ Breast CancerR01CA229697 · NCI · UNIVERSITY OF MINNESOTA · PI Carol A Lange, Douglas Yee · 2020 to 2026
$3.6M
SRC-3/PELP1 complexes drive stem-like phenotypes in luminal breast cancerR01CA236948 · NCI · UNIVERSITY OF MINNESOTA · PI LANGE, CAROL A, OSTRANDER, JULIE H · 2020 to 2024
$2.4M
Targeting Oncogenic PELP1/SRC-3 Signaling Complexes in ER+ Breast CancerK22CA248615 · NCI · UNIVERSITY OF MINNESOTA · PI TRUONG, THU HA · 2023 to 2025
$605k
Nuclear Receptor Regulation of Epigenetics in Endocrine-Related CancersK00CA245796 · NCI · UNIVERSITY OF MINNESOTA · PI GILLIS, NOELLE ELIZABETH · 2021 to 2024
$366k
NCI NIH HHS K00 CA245796NCI NIH HHS K22 CA248615NCI NIH HHS R01 CA229697NCI NIH HHS R01 CA236948
6 · The paper itself

Abstract

Endocrine therapy resistance remains a major challenge in the treatment of advanced estrogen receptor positive (ER+) breast cancer. This can be driven by acquired mutations in the estrogen receptor gene (

Identifiers

PMID41332612
PMCPMC12668012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.