ArticlebioRxiv : the preprint server for biology2025
Inactivation of microtubule organizing center function of the centrosome is required for neuronal development and centriole elimination.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cell differentiation is marked by a dramatic reorganization of the microtubule cytoskeleton that enables diverse cell functions. Mitotic precursor cells arrange microtubules around centrosomes, which become activated as microtubule-organizing centers (MTOCs) through the recruitment of pericentriolar material (PCM) and microtubules to build the mitotic spindle. A hallmark of differentiation is the "inactivation" of centrosomal MTOC function through the loss of PCM and microtubules, yet the function of this inactivation is unknown. We developed a GFP-nanobody-based targeting tool to activate centrosomes in
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