Evidence map›Paper›PMID 41332575›Full record

ArticlebioRxiv : the preprint server for biology2025

Sexually dimorphic role of estrogen receptor α in preserving right ventricular endothelial integrity.

Jiajun Li, Vijaya Karoor, Andrea L Frump, Hanqiu Zhao, Shunning Liang, Chen-Shan Chen Woodcock, Irina Petrache, Zhiyu Dai, Tim Lahm

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jiajun LiDepartment of Pharmacology and Molecular Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO.
Vijaya KaroorDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO.
Andrea L FrumpDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN.
Hanqiu ZhaoDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO.
Shunning LiangDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO.
Chen-Shan Chen WoodcockDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO.
Irina PetracheDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO.
Zhiyu DaiDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO.
Tim LahmDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI Shawn Shafer · 2001 to 2026
$128.0M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Mechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7M
The emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertensionR01HL164791 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea Lee Frump · 2022 to 2026
$3.8M
Novel alveolar mechanisms of hypoxemia in hepatopulmonary syndromeR01HL169509 · NHLBI · UNIVERSITY OF ARIZONA · PI Zhiyu Dai, MICHAEL B FALLON · 2023 to 2026
$3.0M
General Capillary to Arterial Endothelial Cell Transition in Pulmonary ArterialHypertensionR01HL170096 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2023 to 2026
$2.9M
Role of Endothelial SOX17 Deficiency in the Pathogenesis of Pulmonary HypertensionR01HL158596 · NHLBI · WASHINGTON UNIVERSITY · PI Zhiyu Dai · 2022 to 2026
$2.3M
BLRD VA I01 BX002042NCI NIH HHS P30 CA091842NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R01 HL158596NHLBI NIH HHS R01 HL164791NHLBI NIH HHS R01 HL169509NHLBI NIH HHS R01 HL170096
6 · The paper itself

Abstract

Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes. However, the effects of ERα on RV endothelial cells (RVECs), a critical mediator of RV homeostasis and adaptation, are unknown. We hypothesized that ERα exerts sexually dimorphic pro-angiogenic effects on RVECs in vitro and promotes RV vascularization in vivo. Compared to cells isolated from wild-type animals, RVECs from male and female rats with an ERα loss-of-function mutation (ERα

Indexed as

angiogenesisapoptosisendothelial cellsestrogen receptormicrovascular rarefactionmigrationpulmonary hypertensionsingle nucleus RNA-Seq

Identifiers

PMID41332575
PMCPMC12668007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.