Evidence map›Paper›PMID 41332572›Full record

ArticlebioRxiv : the preprint server for biology2025

A nucleic acid labeling chemistry reveals surface DNA on exosomes.

Filip Boskovic, Priyanka Dutta Gupta, Jian Zhang, Yamuna Krishnan, Jack W Szostak

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Filip BoskovicHoward Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0001-7663-2408
Priyanka Dutta GuptaDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.
Jian ZhangHoward Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA.
Yamuna KrishnanDepartment of Chemistry, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0001-5282-8852
Jack W SzostakHoward Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-4131-1203

Funding

Intracellular Electrophysiology: An electrochemical atlas of organellesDP1GM149751 · NIGMS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2022 to 2025
$5.7M
Mechanism and function of intracellular sodium-proton exchangersR01GM147197 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KRISHNAN, YAMUNA, MIRSHAHI, TOORAJ · 2022 to 2025
$2.4M
Calcium homeostasis in organellesR01NS112139 · NINDS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2020 to 2024
$1.8M
NIGMS NIH HHS DP1 GM149751NIGMS NIH HHS R01 GM147197NINDS NIH HHS R01 NS112139
6 · The paper itself

Abstract

Chemical labeling of nucleic acids is essential to pinpoint the structure, localization, and function of RNA and DNA. Yet, reversible sequence-independent chemistries that can label native RNA and DNA remain poorly developed. Here we describe Reversible Uridine Nitrilium-mediated Addition (RUNA), a reversible covalent chemistry that selectively modifies uridine and thymidine residues

Indexed as

exosomesMajor: Biological SciencesMajor: Physical SciencesMinor: ChemistryMinor: Immunology and Inflammationnucleic acid chemical labelingnucleic acid chemistrysurface DNA

Identifiers

PMID41332572
PMCPMC12667867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.