Evidence map›Paper›PMID 41332546›Full record

ArticlebioRxiv : the preprint server for biology2025

Not So Mosaic After All? The Core Genomes of IncP-1 Plasmids Evolve Predominantly Through Vertical Transmission.

David Sneddon, Clinton A Elg, Jack Sullivan, Eva M Top

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David SneddonBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0009-0007-4763-6398
Clinton A ElgBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0001-5468-395X
Jack SullivanBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0003-0216-6867
Eva M TopBioinformatics and Computational Biology Program, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-6380-8782

Funding

THE ORIGIN AND SPREAD OF MOSAIC PLASMIDS ENCODING MULTI-DRUG RESISTANCE(Research Supplement to Promote Diversity)R01AI084918 · NIAID · UNIVERSITY OF IDAHO · PI TOP, EVA M. · 2010 to 2022
$3.6M
NIAID NIH HHS R01 AI084918
6 · The paper itself

Abstract

Broad-host-range plasmids of the incompatibility group IncP-1 play an important role in bacterial evolution by disseminating genes between diverse bacteria. This includes the notable spread of antibiotic resistance genes to bacterial pathogens that increasingly threaten human health. A better understanding of the evolution of genetic elements like IncP-1 plasmids that underwrite bacterial adaptation is required to counter this threat. Here we examined the evolutionary history of IncP-1 plasmids by utilizing the large increase in published genomes and advancing techniques for lineage-based detection of microbial recombination. We specifically tested whether IncP-1 backbone genes evolve primarily

Identifiers

PMID41332546
PMCPMC12667837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.