Evidence map›Paper›PMID 41332545›Full record

ArticlebioRxiv : the preprint server for biology2025

EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND T

Leena Yoon, Lauren N MacMullen, Leonardo Josué Castro Muñoz, Alina Gu, Jamie Bregman, Mary Campion, Avi Srivastava, Rena R Xian, Richard F Ambinder, Andrew Kossenkov and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Leena YoonThe Wistar Institute, Philadelphia, PA 19104.
Lauren N MacMullenThe Wistar Institute, Philadelphia, PA 19104.
Leonardo Josué Castro MuñozThe Wistar Institute, Philadelphia, PA 19104.
Alina GuThe Wistar Institute, Philadelphia, PA 19104.
Jamie BregmanThe Wistar Institute, Philadelphia, PA 19104.
Mary CampionThe Wistar Institute, Philadelphia, PA 19104.
Avi SrivastavaThe Wistar Institute, Philadelphia, PA 19104.
Rena R XianDepartment of Pathology, Johns Hopkins University School of Medicine, MD, 21205 USA.
Richard F AmbinderDepartment of Oncology, Johns Hopkins University School of Medicine, MD, 21205 USA.
Andrew KossenkovThe Wistar Institute, Philadelphia, PA 19104.
Samantha S SoldanThe Wistar Institute, Philadelphia, PA 19104.
Paul M LiebermanThe Wistar Institute, Philadelphia, PA 19104.ORCID 0000-0002-3935-9921

Funding

Virus, Vector and Cell Culture CoreP01CA281867 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERLE S. ROBERTSON · 2023 to 2026
$9.1M
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and SalivaU01CA284811 · NCI · JOHNS HOPKINS UNIVERSITY · PI RICHARD Frederick AMBINDER, Rena Xian · 2023 to 2026
$2.7M
Regulation of EBV Latency by Purine Metabolism and SignalingR01AI153508 · NIAID · WISTAR INSTITUTE · PI TEMPERA, ITALO · 2021 to 2025
$2.3M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
NCI NIH HHS P01 CA281867NCI NIH HHS R50 CA211199NCI NIH HHS U01 CA284811NIAID NIH HHS R01 AI153508
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) infects >95% of the adult population with diverse outcomes ranging from benign latency to cancers and autoimmune diseases. Immunological control of EBV infection is known to be an important determinant of EBV infection outcomes. However, species-specific viral tropism and limited infection models have impeded mechanistic insights into early host-immune control of EBV infection. Here, we use

Indexed as

EBVLIPAmonocytesmultiple sclerosisPBMC (peripheral blood mononuclear cells)transcriptomicsTregvirus-host dynamics

Identifiers

PMID41332545
PMCPMC12667846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.