ArticlemicroPublication biology2025
Nuclear enlargement after confined migration in cancer cells.
Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggressive cell migration is a hallmark of cancer cells. Cancer cells pass through a 3D confined environment during metastasis, which induces mechanical stress on the nucleus. Transwell membranes have been used in research to induce mechanical stress by cell migration in 3D confined space, but other products with microscale pores have not been widely investigated. Here, we report how cancer cells respond to mechanical stress using a TC insert with microscale pores that mimic a 3D confined extracellular environment. As shown in previous studies using the Transwell membranes, our results indicate that the size of microscale pores in the TC insert modulates cancer cell penetration rates and nuclear morphology. Thus, the TC insert is also a useful option to induce mechanical stress by cell migration in a 3D confined environment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.