ReviewFrontiers in aging neuroscience2025
Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review.
Review in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Regulatory T cells in perioperative neurocognitive disorders: a systematic review with structured narrative synthesis from molecular mechanisms to clinical translation.Frontiers in molecular neuroscience · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perioperative neurocognitive disorder (PND) is a common central nervous system complication during the perioperative period, characterized by memory decline, lack of concentration, and other cognitive deficits, which severely affect the quality of life and prognosis of patients. Its incidence remains high. Consequently, the prevention and treatment of PND, along with investigations into its etiology and mechanisms, have become prominent research areas. Recent studies suggest that the occurrence of PND is closely related to the interactions of multiple "important organ-brain axes," such as the gut-brain axis, liver-brain axis, lung-brain axis, heart-brain axis, spleen-brain axis, and kidney-brain axis. Dysfunction of these axes may affect brain homeostasis through neural, immune, and endocrine pathways, leading to perioperative cognitive impairment. Although some progress has been made, the mechanisms underlying PND remain intricate and not fully elucidated. This article aims to comprehensively review how different organ systems influence central nervous system function through multifaceted interactions. It also analyzes the pathological mechanisms of PND and proposes new strategies for perioperative brain protection, with the hope of improving postoperative cognitive function and patients' quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.