Association of healthy lifestyle behaviors with incident gastroesophageal reflux disease in a large population-based prospective cohort.

Zhiyu Wang, Siwei Lin, Hanwen Liu, Jianlong Zhou, Enpei Tang, Zhihui Xi, Jiabin Zheng, Wei Yang

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Article in Preventive medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Zhiyu WangMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Siwei LinMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Hanwen LiuDepartment of Neurosurgery, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou 341000, China.

Jianlong ZhouDepartment of Gastrointestinal Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.

Enpei TangMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Zhihui XiSchool of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.

Jiabin ZhengDepartment of Gastrointestinal Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.

Wei YangMedical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Funding

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6 · The paper itself

Abstract

Objective: Examine the association between healthy lifestyle behaviors (smoking, optimal sleep, high-intensity physical activity, and moderate alcohol consumption) and the risk of Gastroesophageal reflux disease (GERD). Methods: We conducted a prospective cohort study of UK Biobank. Four healthy lifestyle behaviors were assessed at baseline. Participants were followed for 14.2 years until September 15, 2024, and GERD incidence was recorded. Multi variable-adjusted Cox models estimated HRs and 95 % CIs for the association between healthy behaviors and GERD risk. Results: Among 108,239 participants, 8143 (7.5 %) developed GERD during follow-up. Distribution of healthy lifestyle behaviors was: 14.5 % reported none, 38.6 % reported one, 34.1 % reported two, and 12.7 % reported three to four behaviors. Participants with more behaviors had progressively lower GERD risks, with HRs of 0.92 (95 % CI 0.86, 0.98), 0.82 (0.77, 0.87), and 0.68 (0.63, 0.75), respectively (P for trend <0.01). Never smoking (HR: 0.84; 95 % CI: 0.81, 0.88), high physical activity (0.86; 0.83, 0.90), and optimal sleep (0.70; 0.65, 0.74) were independently associated with reduced GERD risk. Conclusions: Adopting multiple healthy lifestyle behaviors significantly reduces GERD risk, emphasizing the importance of lifestyle modifications in GERD prevention.

Indexed as

Gastroesophageal reflux diseaseHealthy lifestyle behaviorsPrevention strategiesProspective cohort studyUK biobank

Identifiers

PMID41332447

DOI10.1016/j.pmedr.2025.103276

PMCPMC12666430

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