Evidence map›Paper›PMID 41332396›Full record

ArticleCirculation. Arrhythmia and electrophysiology2025

Thyrotropin Directly Affects Cardiac Electrophysiology and Is Associated With AF Prevalence.

Ann-Kathrin Rahm, Maximilian N Wunsch, Dominik Seibold, Xenia C Kramp, Axel Schöffel, Pascal Syren, Rasmus Rivinius, Christine Mages, Julia Pfeiffer, Heike Gampp and 16 more

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Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ann-Kathrin Rahm *Department of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0002-7509-887X
Maximilian N Wunsch *Department of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0002-9735-8097
Dominik SeiboldDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Xenia C KrampDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Axel SchöffelDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Pascal SyrenDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Rasmus RiviniusDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0003-1146-6319
Christine MagesDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0002-7617-1418
Julia PfeifferDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Heike GamppDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Teresa CaspariDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Xin WenCardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands (A.-K.R., X.W., J.H.).ORCID 0009-0003-1239-7850
Hauke HundDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Ibrahim AkinDZHK (German Centre for Cardiovascular Research) (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., C.M., J.P., H.G., T.C., H.H., I.A., X.Z., X.F., C.Y., Y.L., N.F., D.T., P.L.).
Xiaobo ZhouDZHK (German Centre for Cardiovascular Research) (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., C.M., J.P., H.G., T.C., H.H., I.A., X.Z., X.F., C.Y., Y.L., N.F., D.T., P.L.).ORCID 0000-0002-5895-0127
Xuehui FanDZHK (German Centre for Cardiovascular Research) (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., C.M., J.P., H.G., T.C., H.H., I.A., X.Z., X.F., C.Y., Y.L., N.F., D.T., P.L.).ORCID 0000-0001-9040-1155
Zenghui MengFirst Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Germany (I.A., X.Z., X.F., Z.M., C.Y., Y.L.).
Chen YanDZHK (German Centre for Cardiovascular Research) (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., C.M., J.P., H.G., T.C., H.H., I.A., X.Z., X.F., C.Y., Y.L., N.F., D.T., P.L.).ORCID 0000-0001-5803-3102
Yingrui LiDZHK (German Centre for Cardiovascular Research) (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., C.M., J.P., H.G., T.C., H.H., I.A., X.Z., X.F., C.Y., Y.L., N.F., D.T., P.L.).
Carsten StichtDepartment of Bioinformatics, Mannheim University Hospital, Germany (C.S.).ORCID 0000-0003-3596-6094
Nina D UllrichDepartment of Physiology and Pathophysiology, Heidelberg University, Germany (N.D.U.).ORCID 0000-0002-1077-3125
Zoltan KenderDepartment of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital, Germany (Z.K.).ORCID 0000-0003-0745-1587
Jordi HeijmanCardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands (A.-K.R., X.W., J.H.).ORCID 0000-0002-1418-108X
Norbert FreyDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0001-7611-378X
Dierk ThomasDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).
Patrick LugenbielDepartment of Cardiology, Medical University Hospital Heidelberg, Germany (A.-K.R., M.N.W., D.S., X.C.K., A.S., P.S., R.R., C.M., J.P., H.G., T.C., H.H., N.F., D.T., P.L.).ORCID 0000-0003-3886-0930

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough hyperthyroidism is known to increase the risk of atrial fibrillation (AF), subclinical hypothyroidism (SH) is an often-underreported condition characterized by elevated thyroid-stimulating hormone (TSH) levels and normal free triiodothyronine/free thyroxine (fT

methodsWe retrospectively included 2311 patients diagnosed with SH between 2007 and 2020 who had an ECG within 7 days of diagnosis. Logistic regression analysis identified factors independently associated with AF in patients with SH. Effects of different TSH doses on ion channel mRNA and protein levels were analyzed in HL-1 and neonatal rat cardiomyocytes. Video analysis with MYOCYTER, patch-clamp, optical mapping, and computational modeling were used to study automaticity and action potential characteristics after TSH application.

resultsAF was documented more often with higher TSH levels (4-10 mU/L TSH: 32.1% versus >10 mU/L TSH: 44.6%;

conclusionsIndividuals with SH exhibit an increased prevalence of AF, which is likely in part due to a direct effect of TSH on ion channel expression in cardiomyocytes via the TSHR/cAMP/PKA pathway.

Indexed as

Atrial FibrillationHeart RateHypothyroidismMyocytes, CardiacThyrotropinAction PotentialsAgedAnimalsElectrocardiographyFemaleHumansMaleMiddle AgedPrevalenceRatsReceptors, ThyrotropinReceptors, ThyrotropinThyrotropinatrial fibrillationhypothyroidismion channelsreceptorthyrotropin

Identifiers

PMID41332396
PMCPMC12711286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.