Evidence map›Paper›PMID 41332368›Full record

ArticleStem cells and development2025

The Specification and Functional Maturation of Sub-Cerebral Projection Neurons Derived from Human Induced Pluripotent Stem Cells.

Zachary Jordan, Anukriti Singh, Seth Kattapong-Graber, Sonal Goswami, Neville E Sanjana, Emanuela Zuccaro, Feng Zhang, Kevin Eggan, Jenny Hsieh, Brian P Hermann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zachary JordanDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Anukriti SinghDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Seth Kattapong-GraberDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Sonal GoswamiDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Neville E SanjanaNew York Genome Center, New York, New York, USA.
Emanuela ZuccaroDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Feng ZhangBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kevin EgganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Jenny HsiehDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Brian P HermannDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.
Jean M HebertDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Asif Mirza MaroofDepartment of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas, USA.

Funding

Spatial analyses of marmoset germline developmentU01DA054170 · NIDA · UNIVERSITY OF TEXAS SAN ANTONIO · PI HERMANN, BRIAN PETER, HSIEH, JENNY · 2021 to 2025
$12.1M
Precision models of ARX-associated neurodevelopmental disordersR01NS113516 · NINDS · UNIVERSITY OF TEXAS SAN ANTONIO · PI GOLDEN, JEFFREY A, HSIEH, JENNY · 2019 to 2023
$2.6M
Molecular control of aberrant adult-born granule cells in epilepsy.R01NS124855 · NINDS · UNIVERSITY OF TEXAS SAN ANTONIO · PI Jenny Hsieh · 2023 to 2026
$1.9M
Origin and functional significance of the spermatogonial stem cell transcriptome barcodeR01HD090007 · NICHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI HERMANN, BRIAN PETER · 2017 to 2021
$1.5M
Development of small molecule inhibitors of RBM46 as novel male contraceptivesR61HD114223 · NICHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI GEYER, CHRISTOPHER BENNETT, HERMANN, BRIAN PETER · 2024 to 2025
$779k
The Role of Cortical Projection Neurons Susceptible to Progressive Degeneration wIth AgingR00AG047335 · NIA · UNIVERSITY OF TEXAS SAN ANTONIO · PI MAROOF, ASIF MIRZA · 2017 to 2019
$737k
Transcriptional regulatory networks in spermatogonial stem cellsK99HD062687 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI HERMANN, BRIAN PETER · 2010 to 2011
$221k
The Role of Cortical Projection Neurons Susceptible to Progressive Degeneration wK99AG047335 · NIA · HARVARD UNIVERSITY · PI MAROOF, ASIF MIRZA · 2014 to 2015
$178k
NIA NIH HHS K99 AG047335NIA NIH HHS R00 AG047335NICHD NIH HHS K99 HD062687NICHD NIH HHS R01 HD090007NICHD NIH HHS R61 HD114223NIDA NIH HHS U01 DA054170NINDS NIH HHS R01 NS113516NINDS NIH HHS R01 NS124855
6 · The paper itself

Abstract

Human induced pluripotent stem cells (hiPSC) are an invaluable resource for investigating the molecular mechanisms regulating cell fate specification during brain development. However, most directed differentiation methods exhibit significant cell fate heterogeneity and require several months to become functional. To address this challenge, we developed a green fluorescent protein (GFP) reporter system in hiPSC by targeting the genomic locus of Forebrain Enriched Zinc Finger 2 (

Indexed as

Cell DifferentiationInduced Pluripotent Stem CellsNeuronsCoculture TechniquesGreen Fluorescent ProteinsHumansMotor NeuronsNeurogenesisSynapsesGreen Fluorescent Proteinsfate specificationFEZF2-GFP reportersub-cerebral projection neurons

Identifiers

PMID41332368
PMCPMC13162234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.