Evidence map›Paper›PMID 41332333›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Contribution of Gli1

Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haixiao WangPediatric Research Institute, Pediatric Discipline Group, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.ORCID https://orcid.org/0000-0002-6962-8408
Xiuzhen HuangNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute, of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Jialing MouNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute, of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Enci WangDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200031, China.
Yan LiShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264199, China.
Wenjuan PuNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute, of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Yao XieDepartment of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Xiaoling GuoScientific Research Department, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Lixin WangDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200031, China.
Maoping ChuPediatric Research Institute, Pediatric Discipline Group, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Bin ZhouPediatric Research Institute, Pediatric Discipline Group, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.ORCID https://orcid.org/0000-0001-5278-5522
Chao NiuPediatric Research Institute, Pediatric Discipline Group, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.ORCID https://orcid.org/0009-0006-2639-3617

Funding

CAS Project for Young Scientists in Basic Research YSBR-012China Postdoctoral Science Foundation 2023TQ0246China Postdoctoral Science Foundation GZB20230534National Key Research & Development Program of China 2022YFA1104200National Key Research & Development Program of China 2023YFA1800700National Key Research & Development Program of China 2023YFA1801300National Key Research & Development Program of China 2024YFA1803302National Science Foundation of China 32170848National Science Foundation of China 32370783National Science Foundation of China 32370802National Science Foundation of China 32370897National Science Foundation of China 82088101National Science Foundation of China 82270441National Science Foundation of China 82400561Shenzhen Medical Research Fund C2504001the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China LHDMY23H070001the "Pioneer" and "Leading Goose" R&D Program of Zhejiang 2023C03030Youth Innovation Promotion Association CAS, Shanghai Pilot Program for Basic Research - CAS, Shanghai Branch JCYJ-SHFY-2021-0
6 · The paper itself

Abstract

Adventitial stem cells (ASCs), identified by Gli1 expression, have been proposed as key contributors to the vascular smooth muscle cell (SMC) population during atherosclerosis development. However, their precise role remains a subject of debate. To clarify this, a Gli1-CreER lineage tracing tool to track these cells in an atherosclerosis model is initially used. This fate-mapping studies revealed that Gli1

Indexed as

AdventitiaAtherosclerosisMyocytes, Smooth MuscleStem CellsVascular System InjuriesZinc Finger Protein GLI1AnimalsCell DifferentiationDisease Models, AnimalMiceMuscle, Smooth, VascularGli1 protein, mouseZinc Finger Protein GLI1atherosclerosisfate‐mappinglineage tracingstem cellvascular smooth muscle cell

Identifiers

PMID41332333
PMCPMC12970261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.