Evidence map›Paper›PMID 41332316›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Autopolyploidization-Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa.

Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Haoyuan DongCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.ORCID https://orcid.org/0009-0000-0429-2352
Yanhong LiuState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Yuanming LiuCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Shuxin XuanCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Huanhuan ChenCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Lai WeiCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Guibao ZhangCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Hongcui PeiState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zilong DaiCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Yanhua WangCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Jinzhu QiaoCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Shuangxia LuoCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Xueping ChenCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Yiguo HongCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Jianjun ZhaoCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Shuxing ShenCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.
Zefu LuState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Aixia GuCollege of Horticulture, State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable Industry in Hebei, Hebei Agricultural University, Baoding, Hebei, 071000, China.ORCID https://orcid.org/0000-0002-1481-7359

Funding

Hebei Provincial Natural Science Fund for Distinguished Young Scholars C2020204063Innovative Research Group Project of Hebei Natural Science Foundation C2020204111National Key Research and Development Program of China 2023YFD1200101-08National Natural Science Foundation of China 31930098National Natural Science Foundation of China 32172560National Natural Science Foundation of China 32402565Natural Science Foundation of Hebei Province C2023204167Natural Science Foundation of Hebei Province C2024204110Outstanding Young Scientist Foundation of NSFC (Overseas)State Key Laboratory of North China Crop Improvement and Regulation NCCIR2021KF-6S&T Program of Hebei 24466301D
6 · The paper itself

Abstract

Whole-genome duplication is a key evolutionary mechanism influencing gene regulation and trait development; however, how successive genome duplications reshape chromatin at the genome-wide scale and thereby drive phenotypic innovation remains unclear. To dissect the effects of genome doubling on chromatin dynamics, gene expression, and associated trait differences, monoploid, diploid, and autotetraploid Brassica rapa L. ssp. pekinensis lines are generated with an identical genomic background and performed integrative analyses using ATAC-seq, ChIP-seq (H3K4me3, H3K27ac, H3K27me3), and RNA-seq. By establishing this uniform ploidy series, nonlinear and stage-specific chromatin and transcriptional reprogramming during autopolyploidization are revealed. Increased ploidy reprogrammed chromatin accessibility, characterized by reduced proximal and expanded distal regions, with effects particularly pronounced during the monoploid-to-diploid transition. Corresponding changes in H3K4me3 modifications near transcription start sites alter global gene expression. Numerous transcription factor genes are identified, of which BrGRF13 and BrARF11 are crucial regulators of leaf size and polarity during head development. Overall, this study elucidates the molecular basis by which ploidy variation drives chromatin remodeling and phenotypic divergence, providing new insights into how genome duplication shapes plant traits and informs polyploid crop improvement.

Indexed as

Brassica rapaChromatin Assembly and DisassemblyPlant LeavesChromatinGene Expression Regulation, PlantGenome, PlantPolyploidyChromatinautopolyploidizationBrARF11Brassica rapaBrGRF13chromatin remodelinghistone modifications

Identifiers

PMID41332316
PMCPMC12904041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.